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Increased Ca 2+ Transient Underlies RyR2-Related Left Ventricular Noncompaction

16 Jun 2023

Abstract excerpt

Background: A loss-of-function cardiac ryanodine receptor (RyR2) mutation, I4855M +/– , has recently been linked to a new cardiac disorder termed RyR2 Ca 2+ release deficiency syndrome (CRDS) as well as left ventricular noncompaction (LVNC). The mechanism by which RyR2 loss-of-function causes CRDS has been extensively studied, but the mechanism underlying RyR2 loss-of-function-associated LVNC is unknown. Here, we...

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PMID: 37325910
DOI: 10.1161/circresaha.123.322504

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