Article
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Circulation research - 16 Mar 2012
Zhang Hongyu, Makarewich Catherine A, Kubo Hajime, Wang Wei, Duran Jason M, Li Ying, Berretta Remus M, Koch Walter J, Chen Xiongwen, Gao Erhe, Valdivia Héctor H, Houser Steven R
Abstract excerpt
RATIONALE: Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to cardiac arrhythmias and heart failure (HF) after myocardial infarction (MI). It has been proposed that protein kinase A (PKA) hyperphosphorylation of the RyR2 at a single residue, Ser-2808, is a critical mediator of RyR dysfunction, depressed cardiac performance, and HF after MI. OBJECTIVE: We used a mouse model (RyRS2808A)...
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