Article
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.
Annals of the rheumatic diseases - 1 Jul 2012
Bos Steffan D, Bovée Judith V M G, Duijnisveld Bouke J, Raine Emma V A, van Dalen Wouter J, Ramos Yolande F M, van der Breggen Ruud, Nelissen Rob G H H, Slagboom P Eline, Loughlin John, Meulenbelt Ingrid
Abstract excerpt
OBJECTIVE: Genetic variation at the type II deiodinase (D2) gene (DIO2) was previously identified as osteoarthritis (OA) risk factor. To investigate mechanisms possibly underlying this association, we assessed D2 protein in healthy and OA-affected cartilage and investigated allelic balance of the...
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