Article
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.
Annals of the rheumatic diseases - 1 Aug 2015
Bomer Nils, den Hollander Wouter, Ramos Yolande F M, Bos Steffan D, van der Breggen Ruud, Lakenberg Nico, Pepers Barry A, van Eeden Annelies E, Darvishan Arash, Tobi Elmar W, Duijnisveld Bouke J, van den Akker Erik B, Heijmans Bastiaan T, van Roon-Mom Willeke Mc, Verbeek Fons J, van Osch Gerjo J V M, Nelissen Rob G H H, Slagboom P Eline, Meulenbelt Ingrid
Abstract excerpt
OBJECTIVES: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. METHODS: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG-dinucleotides and the respective DIO2 expression in OA-affected and...
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