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The Physiological Functions and Polymorphisms of Type II Deiodinase

27 Apr 2023

Abstract excerpt

Type II deiodinase (DIO2) is thought to provide triiodothyronine (T3) to the nucleus to meet intracellular needs by deiodinating the prohormone thyroxine. DIO2 is expressed widely in many tissues and plays an important role in a variety of physiological processes, such as controlling T3 content in developing tissues (e.g., bone, muscles, and skin) and the adult brain, and regulating adaptive thermogenesis in...

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PMID: 37150515
DOI: 10.3803/enm.2022.1599

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