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Article

DIO2 Thr92Ala Reduces Deiodinase-2 Activity and Serum-T3 Levels in Thyroid-Deficient Patients.

The Journal of clinical endocrinology and metabolism - 1 May 2017

Castagna Maria Grazia, Dentice Monica, Cantara Silvia, Ambrosio Raffaele, Maino Fabio, Porcelli Tommaso, Marzocchi Carlotta, Garbi Corrado, Pacini Furio, Salvatore Domenico

Abstract excerpt

Context: A substantial proportion of athyreotic levothyroxine (LT4)-treated patients experience hypothyroid-like symptoms. During LT4 replacement, levels of the active hormone triiodothyronine (T3) strictly depend on type 2-deiodinase (D2)-mediated activation of LT4. The Thr92Ala polymorphism and the 258 G/A in the DIO2 gene have been associated with various clinical conditions. Objectives: To investigate the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28324063
DOI: 10.1210/jc.2016-2587

Genes

DIO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DIO2 Thr92Ala Reduces Deiodinase-2 Activity and Serum-T3 Levels in Thyroid-Deficient Patients.PMID 28324063Read ↗

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