Article
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis.
Human molecular genetics - 15 Jun 2008
Meulenbelt Ingrid, Min Josine L, Bos Steffan, Riyazi Naghmeh, Houwing-Duistermaat Jeanine J, van der Wijk Henk-Jan, Kroon Herman M, Nakajima Masahiro, Ikegawa Shiro, Uitterlinden André G, van Meurs Joyce B J, van der Deure Wendy M, Visser Theo J, Seymour Albert B, Lakenberg Nico, van der Breggen Ruud, Kremer Dennis, van Duijn Cornelia M, Kloppenburg Margreet, Loughlin John, Slagboom P Eline
Abstract excerpt
Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention is available to attenuate the cartilage degeneration. To identify a new osteoarthritis susceptibility locus, a genome-wide linkage scan and combined linkage association analysis were applied to 179 affected siblings and four trios with generalized osteoarthritis (The GARP study). We tested, for...
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