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Article

The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2012

Xiang Yufei, Peng Jian, Tai Ningwen, Hu Changyun, Zhou Zhiguang, Wong F Susan, Wen Li

Abstract excerpt

B cells play a critical role in the pathogenesis of autoimmune diabetes. To investigate the mechanisms by which B cell depletion therapy attenuates islet β cell loss and particularly to examine the effect of B cells on both diabetogenic and regulatory Ag-specific T cells, we generated a transgenic BDC2.5NOD mouse expressing human CD20 on B cells. This allowed us to deplete B cells for defined time periods and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22490442
DOI: 10.4049/jimmunol.1103055
PMCID: PMC4361183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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