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Article

Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2011

Hoyne Gerard F, Flening Eleanor, Yabas Mehmet, Teh Charis, Altin John A, Randall Katrina, Thien Christine B F, Langdon Wallace Y, Goodnow Christopher C

Abstract excerpt

The E3 ubiquitin ligase Cbl-b regulates T cell activation thresholds and has been associated with protecting against type 1 diabetes, but its in vivo role in the process of self-tolerance has not been examined at the level of potentially autoaggressive CD4(+) T cells. In this study, we visualize...

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Identifiers

PMID: 21248249
DOI: 10.4049/jimmunol.1002296

Genes

AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21248249-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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