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Article

Spectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμ(null) mice after polyclonal B cell reconstitution.

Journal of translational medicine - 2 Jul 2011

Vong Allen M, Daneshjou Nazila, Norori Patricia Y, Sheng Huiming, Braciak Todd A, Sercarz Eli E, Gabaglia Claudia Raja

Abstract excerpt

BACKGROUND: Non Obese Diabetic mice lacking B cells (NOD.Igμ(null) mice) do not develop diabetes despite their susceptible background. Upon reconstitution of B cells using a chimera approach, animals start developing diabetes at 20 weeks of age. METHODS: We have used the spectratyping technique to follow the T cell receptor (TCR) V beta repertoire of NOD.Igμ(null) mice following B cell reconstitution. This...

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Source

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Identifiers

PMID: 21722394
DOI: 10.1186/1479-5876-9-101
PMCID: PMC3141497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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