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Article

B-cell depletion immunotherapy in pemphigus: effects on cellular and humoral immune responses.

The Journal of investigative dermatology - 1 Dec 2008

Mouquet Hugo, Musette Philippe, Gougeon Marie-Lyse, Jacquot Serge, Lemercier Brigitte, Lim Annick, Gilbert Danièle, Dutot Ingrid, Roujeau Jean C, D'Incan Michel, Bedane Christophe, Tron François, Joly Pascal

Abstract excerpt

Pemphigus are B-cell-mediated autoimmune diseases affecting skin and mucous membranes. They are characterized by the production of pathogenic autoantibodies directed against desmogleins (Dsg). In this prospective study, we treated 21 pemphigus patients with rituximab and analyzed immunological modifications induced by anti-CD20 immunotherapy. The total depletion of peripheral B cells led to a significant decrease...

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Share to ADP-ribosyl Cyclase 1
Share to Antibodies, Monoclonal, Murine-Derived

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Antigens, CD19

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Source

Identifiers

PMID: 18563177
DOI: 10.1038/jid.2008.178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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