Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.

doi:10.3851/IMP2095

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Article

Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.

Antiviral therapy - 1 Jan 2012

Schipani Alessandro, Egan Deirdre, Dickinson Laura, Davies Gerry, Boffito Marta, Youle Mike, Khoo Saye H, Back David J, Owen Andrew

Abstract excerpt

BACKGROUND: The organic anion transporting polypeptides (OATP)/SLCO family represents an important class of hepatic drug uptake transporters that mediate the sodium independent transport of a diverse range of amphipathic organic compounds, including the protease inhibitors. The SLCO1B1 521T>C (rs4149056) single nucleotide polymorphism (SNP) has been consistently associated with reduced transport activity in vivo,...

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Identifiers

PMID: 22477766
DOI: 10.3851/IMP2095
PMCID: PMC3443796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.PMID 22477766Read ↗

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