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Article

ABCB1 polymorphisms and the concentrations of lopinavir and ritonavir in blood, semen and saliva of HIV-infected men under antiretroviral therapy.

Pharmacogenomics - 1 Feb 2009

Estrela Rita de Cassia, Ribeiro Fabio S, Barroso Paulo F, Tuyama Mari, Gregório Sheila P, Dias-Neto Emmanuel, Struchiner Cláudio J, Suarez-Kurtz Guilherme

Abstract excerpt

INTRODUCTION: Lopinavir and ritonavir are frequently included in highly active antiretroviral therapy (HAART) regimens for HIV infection. These drugs are substrates, and may also inhibit and/or induce the P-glycoprotein (ABCB1) transporter, encoded by the polymorphic ABCB1 gene. We investigated the impact of three common exonic ABCB1 polymorphisms on the concentrations of lopinavir and ritonavir in blood, semen...

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Identifiers

PMID: 19207033
DOI: 10.2217/14622416.10.2.311

Genes

ABCB1

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