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HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.

Pharmacogenetics and genomics - 1 Feb 2010

Hartkoorn Ruben C, Kwan Wai San, Shallcross Victoria, Chaikan Ammara, Liptrott Neill, Egan Deirdre, Sora Enrique Salcedo, James Chloë E, Gibbons Sara, Bray Pat G, Back David J, Khoo Saye H, Owen Andrew

Abstract excerpt

OBJECTIVE: OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and xenobiotics and have been reported to have functional single nucleotide polymorphisms (SNPs). We have assessed the substrate specificities of these transporters for a...

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Identifiers

PMID: 20051929
DOI: 10.1097/FPC.0b013e328335b02d
PMCID: PMC4859410

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