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Article

ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir.

Pharmacogenetics and genomics - 1 Apr 2010

Lubomirov Rubin, di Iulio Julia, Fayet Aurélie, Colombo Sara, Martinez Raquel, Marzolini Catia, Furrer Hansjakob, Vernazza Pietro, Calmy Alexandra, Cavassini Matthias, Ledergerber Bruno, Rentsch Katharina, Descombes Patrick, Buclin Thierry, Decosterd Laurent A, Csajka Chantal, Telenti Amalio

Abstract excerpt

BACKGROUND: An ADME (absorption, distribution, metabolism and excretion)-pharmacogenetics association study may identify functional variants relevant to the pharmacokinetics of lopinavir co-formulated with ritonavir (LPV/r), a first-line anti-HIV agent. METHODS: An extensive search of literature and web resources helped select ADME genes and single nucleotide polymorphisms (SNPs, functional and HapMap tagging...

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Identifiers

PMID: 20139798
DOI: 10.1097/FPC.0b013e328336eee4

Genes

ABCC2

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