Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism.

Pharmacogenetics and genomics - 1 Dec 2010

Siccardi Marco, D'Avolio Antonio, Nozza Silvia, Simiele Marco, Baietto Lorena, Stefani Francesca Romana, Moss Darren, Kwan Wai-San, Castagna Antonella, Lazzarin Adriano, Calcagno Andrea, Bonora Stefano, Back David, Di Perri Giovanni, Owen Andrew

Abstract excerpt

BACKGROUND: Organic anion transporting polypeptides (OATPs) are emerging as major determinants of pharmacokinetics for numerous drugs, with the 1B1 isoform-mediating hepatic uptake. The 521 T>C polymorphism has been correlated earlier with higher plasma concentrations of several drugs and the aim of this study was to determine whether this polymorphism influences trough concentrations of maraviroc. METHODS: The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, Liquid
Share to Cyclohexanes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver-Specific Organic Anion Transporter 1

Share to Mass Spectrometry

Share to Oocytes

Share to Organic Anion Transporters

Share to Triazoles

Share to Xenopus laevis

Source

Identifiers

PMID: 21217360
DOI: 10.1097/FPC.0b013e3283402efb

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism.PMID 21217360Read ↗

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.Semantic proximity Read ↗

In vitro characterization of SLCO2B1 genetic variants.Semantic proximity Read ↗

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality.Semantic proximity Read ↗

Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.Semantic proximity Read ↗

The role of OATP1B1 and OATP1B3 transporter polymorphisms in drug disposition and response to anticancer drugs: a review of the recent literatureSemantic proximity Read ↗

International Transporter Consortium Commentary on Clinically Important Transporter PolymorphismsSemantic proximity Read ↗

Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of DrugsSemantic proximity Read ↗

Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene.Semantic proximity Read ↗

Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method.Semantic proximity Read ↗

Transport of nucleoside analogs across the plasma membrane: a clue to understanding drug-induced cytotoxicity.Semantic proximity Read ↗

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).Semantic proximity Read ↗

ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.