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Article

Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.

Pharmacogenomics - 1 Oct 2009

Elens Laure, Yombi Jean-Cyr, Lison Dominique, Wallemacq Pierre, Vandercam Bernard, Haufroid Vincent

Abstract excerpt

AIM: Lopinavir (LPV) is a potent protease inhibitor used in combination with low doses of ritonavir in the treatment of HIV-infected patients. LPV pharmacokinetics is characterized by a large interindividual variability requiring the use of therapeutic drug monitoring in different clinical situations. While the sources of this variability are still unknown, several genetic polymorphisms in biotransformation...

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Source

Identifiers

PMID: 19842932
DOI: 10.2217/pgs.09.88

Genes

ABCC2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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