CYP3A4*22 (c.522-191 C>T; rs35599367) is associated with lopinavir pharmacokinetics in HIV-positive adults.

doi:10.1097/FPC.0000000000000073

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CYP3A4*22 (c.522-191 C>T; rs35599367) is associated with lopinavir pharmacokinetics in HIV-positive adults.

Pharmacogenetics and genomics - 1 Sept 2014

Olagunju Adeniyi, Schipani Alessandro, Siccardi Marco, Egan Deirdre, Khoo Saye, Back David, Owen Andrew

Abstract excerpt

The CYP3A4*22 (c.522-191 C>T; rs35599367) single nucleotide polymorphism has been associated with lower CYP3A4 mRNA expression and activity. We investigated the association of CYP3A4*22 with the pharmacokinetics of lopinavir through a population pharmacokinetic approach. The minor allele frequency for CYP3A4*22 was 0.035, and seven of 375 patients had a combination of CYP3A4*22 and SLCO1B1 521T>C alleles. Lack of...

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PMID: 24950369
DOI: 10.1097/FPC.0000000000000073

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