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Article

CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children.

Therapeutic drug monitoring - 1 Aug 2011

Rakhmanina Natella Y, Neely Michael N, Van Schaik Ron H N, Gordish-Dressman Heather A, Williams Keetra D, Soldin Steven J, van den Anker John N

Abstract excerpt

OBJECTIVE: CYP3A5, MDR1 (ABCB1), and OATP1 (SLCO1B1) polymorphisms have been associated with variability in the pharmacokinetics (PK) of protease inhibitors. The aim of this study was to investigate the influence of CYP3A5 A6986G, ABCB1 (C3435T and G2677T), and SLCO1B1 (T521C and A388AG) polymorphisms on the PK and virologic outcome of lopinavir/ritonavir (LPV/RTV) in HIV-infected children. DESIGN AND METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21743379
DOI: 10.1097/FTD.0b013e318225384f
PMCID: PMC3139013

Genes

ABCB1

Variants

Provenance

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