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Article

The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.

Current biology : CB - 2 Feb 2015

Folco H Diego, Campbell Christopher S, May Karen M, Espinoza Celso A, Oegema Karen, Hardwick Kevin G, Grewal Shiv I S, Desai Arshad

Abstract excerpt

In most eukaryotes, centromeres are defined epigenetically by presence of the histone H3 variant CENP-A [1-3]. CENP-A-containing chromatin recruits the constitutive centromere-associated network (CCAN) of proteins, which in turn directs assembly of the outer kinetochore to form microtubule attachments and ensure chromosome segregation fidelity [4-6]. Whereas the mechanisms that load CENP-A at centromeres are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25619765
DOI: 10.1016/j.cub.2014.11.060
PMCID: PMC4318777

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The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.PMID 25619765Read ↗

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