Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reaction.

The Journal of infectious diseases - 1 May 2012

Sousa Ana Lucia M, Fava Vinicius M, Sampaio Lucas H, Martelli Celina Maria T, Costa Mauricio B, Mira Marcelo T, Stefani Mariane M A

Abstract excerpt

In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and permanent disabilities. A previous study on plasma levels of 27 cytokines in patients with T1R or T2R and controls with nonreactional leprosy identified the gene for interleukin 6 (IL-6) as a candidate for genetic analysis. Two nested case-control studies were built from a cohort of 409 patients with leprosy from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brazil
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Interleukin-6

Share to Leprosy

Share to Logistic Models

Share to Multivariate Analysis

Share to Selection, Genetic

Source

Identifiers

PMID: 22459738
DOI: 10.1093/infdis/jis208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reaction.PMID 22459738Read ↗

Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.Semantic proximity Read ↗

A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy.Semantic proximity Read ↗

Polymorphisms in genes TLR1, 2 and 4 are associated with differential cytokine and chemokine serum production in patients with leprosy.Semantic proximity Read ↗

Genetics of host response in leprosy.Semantic proximity Read ↗

Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica.Semantic proximity Read ↗

PARK2 and proinflammatory/anti-inflammatory cytokine gene interactions contribute to the susceptibility to leprosy: a case-control study of North Indian population.Semantic proximity Read ↗

Bridging pleiotropic mechanisms in leprosy type-1 reactions and neurodegenerative diseases.Semantic proximity Read ↗

Genetic variations and interactions in anti-inflammatory cytokine pathway genes in the outcome of leprosy: a study conducted on a MassARRAY platform.Semantic proximity Read ↗

Prediction of the Occurrence of Leprosy Reactions Based on Bayesian NetworksSemantic proximity Read ↗

Bridging Pleiotropic Mechanisms in Leprosy Type-1 Reactions and Neurodegenerative diseasesSemantic proximity Read ↗

Association of TNFSF8 regulatory variants with excessive inflammatory responses but not leprosy per se.Semantic proximity Read ↗

Role of HLA, KIR, MICA, and cytokines genes in leprosy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.