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Article

Polymorphisms in genes TLR1, 2 and 4 are associated with differential cytokine and chemokine serum production in patients with leprosy.

Memorias do Instituto Oswaldo Cruz - 1 Apr 2017

Santana Nadja de Lima, Rêgo Jamile Leão, Oliveira Joyce Moura, Almeida Lucas Frederico de, Braz Marcos, Machado Lídia Maria Medeiros, Machado Paulo Roberto Lima, Castellucci Léa Cristina

Abstract excerpt

BACKGROUND: Leprosy or hansen's disease is a spectral disease whose clinical forms mostly depends on host's immune and genetic factors. Different Toll-like receptors (TLR) variants have been described associated with leprosy, but with some lack of replication across different populations. OBJECTIVES: To evaluate the role of polymorphisms in genes TLR1, TLR2 and TLR4 and susceptibility to leprosy in a genetic case...

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Source

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Identifiers

PMID: 28327786
DOI: 10.1590/0074-02760160366
PMCID: PMC5354609

Genes

TLR1
TLR2
TLR4
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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