Article

Bridging Pleiotropic Mechanisms in Leprosy Type-1 Reactions and Neurodegenerative diseases

2025-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Leprosy is an infectious disease that affects predominantly the skin and peripheral nervous system. Sudden episodes of hyperinflammation, known as Type 1 Reactions (T1R), are a main contributor to permanent nerve damage in leprosy. The genetic component associated with the neuro-inflammatory phenotype of T1R displays pleiotropic effects with Parkinson’s disease (PD) risk genes. In this study, we...

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Literature Corpus work: ddf057b4-5fa0-59eb-ad6e-0bfd38d6a781
DOI: 10.1101/2025.06.05.25329059

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