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Article

Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica.

Pain - 1 Mar 2005

Noponen-Hietala Noora, Virtanen Iita, Karttunen Riitta, Schwenke Susanne, Jakkula Eveliina, Li Hong, Merikivi Riitta, Barral Sandra, Ott Jürg, Karppinen Jaro, Ala-Kokko Leena

Abstract excerpt

Intervertebral disc disease (IDD) characterized by sciatica is a common disorder affecting about 5% of individuals. Environmental factors can predispose to this disease, but IDD has a strong genetic background. Recent evidence suggests that inflammation is one of the key factors in the etiology of IDD. Here, a possible role of the inflammatory mediator genes was studied in 155 patients with IDD-related sciatica...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15733644
DOI: 10.1016/j.pain.2004.12.015

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IFNG

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