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Article

Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.

PLoS neglected tropical diseases - 1 Jul 2017

Sales-Marques Carolinne, Cardoso Cynthia Chester, Alvarado-Arnez Lucia Elena, Illaramendi Ximena, Sales Anna Maria, Hacker Mariana de Andréa, Barbosa Mayara Garcia de Mattos, Nery José Augusto da Costa, Pinheiro Roberta Olmo, Sarno Euzenir Nunes, Pacheco Antonio Guilherme, Moraes Milton Ozório

Abstract excerpt

The pathways that trigger exacerbated immune reactions in leprosy could be determined by genetic variations. Here, in a prospective approach, both genetic and non-genetic variables influencing the amount of time before the development of reactional episodes were studied using Kaplan-Meier survival curves, and the genetic effect was estimated by the Cox proportional-hazards regression model. In a sample including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 28715406
DOI: 10.1371/journal.pntd.0005754
PMCID: PMC5531687

Genes

NOD2
IFNG
LTA
SOD2
TLR1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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