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Article

Bridging pleiotropic mechanisms in leprosy type-1 reactions and neurodegenerative diseases.

Scientific reports - 22 Dec 2025

Fava Vinicius M, Perico Jônatas, Orlova Marianna, Dallmann-Sauer Monica, Xu Yong Zhong, Thuc Nguyen Van, Thai Vu Hong, Belone Andrea F, Latini Ana Carla P, Schurr Erwin

Abstract excerpt

Leprosy is an infectious disease of the skin and peripheral nervous system. Sudden episodes of hyperinflammation, known as Type 1 Reactions (T1R), are a main contributor to permanent nerve damage in leprosy. The genetic component associated with the neuro-inflammatory phenotype of T1R displays pleiotropic effects with Parkinson's disease (PD). In this study, we explored the genetic overlap between PD and T1R and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41430073
DOI: 10.1038/s41598-025-30734-7
PMCID: PMC12749272

Genes

PRKN
GAK
PINK1
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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