Article
A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy.
PLoS genetics - 1 Feb 2017
Fava Vinicius M, Manry Jeremy, Cobat Aurélie, Orlova Marianna, Van Thuc Nguyen, Moraes Milton O, Sales-Marques Carolinne, Stefani Mariane M A, Latini Ana Carla P, Belone Andrea F, Thai Vu Hong, Abel Laurent, Alcaïs Alexandre, Schurr Erwin
Abstract excerpt
Leprosy Type-1 Reactions (T1Rs) are pathological inflammatory responses that afflict a sub-group of leprosy patients and result in peripheral nerve damage. Here, we employed a family-based GWAS in 221 families with 229 T1R-affect offspring with stepwise replication to identify risk factors for T1R. We discovered, replicated and validated T1R-specific associations with SNPs located in chromosome region 10p21.2....
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