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Article

Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning.

European archives of psychiatry and clinical neuroscience - 1 Dec 2012

Zilles David, Meyer Jobst, Schneider-Axmann Thomas, Ekawardhani Savira, Gruber Eva, Falkai Peter, Gruber Oliver

Abstract excerpt

Working memory deficits are found in different psychiatric populations and are most pronounced in schizophrenia. There is preliminary evidence from pharmacological studies that the verbal and visuospatial subcomponents of working memory are subject to differential neurotransmitter modulation. Here, we investigated the impact of well-known polymorphisms of the dopamine transporter gene (SLC6A3, DAT) and the...

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Share to Catechol O-Methyltransferase
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Source

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Identifiers

PMID: 22454241
DOI: 10.1007/s00406-012-0312-0
PMCID: PMC3491187

Genes

COMT
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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