Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.

doi:10.1590/1516-4446-2016-1987

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Article

Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) - 1 Jan 2000

Matsuzaka Camila T, Christofolini Denise, Ota Vanessa K, Gadelha Ary, Berberian Arthur A, Noto Cristiano, Mazzotti Diego R, Spindola Leticia M, Moretti Patricia N, Smith Marilia A C, Melaragno Maria I, Belangero Sintia I, Bressan Rodrigo A

Abstract excerpt

OBJECTIVE: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. METHODS: We evaluated the role...

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PMID: 28273278
DOI: 10.1590/1516-4446-2016-1987
PMCID: PMC7111404

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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