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Article

Ion channels induced by the prion protein: mediators of neurotoxicity.

Prion - 1 Jan 2000

Solomon Isaac H, Biasini Emiliano, Harris David A

Abstract excerpt

Prion diseases comprise a group of rapidly progressive and invariably fatal neurodegenerative disorders for which there are no effective treatments. While conversion of the cellular prion protein (PrP(C)) to a β-sheet rich isoform (PrP(Sc) ) is known to be a critical event in propagation of infectious prions, the identity of the neurotoxic form of PrP and its mechanism of action remain unclear. Insights into this...

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Identifiers

PMID: 22453177
DOI: 10.4161/pri.6.1.18627
PMCID: PMC3338964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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