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Article

An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity.

The Journal of biological chemistry - 22 Apr 2011

Solomon Isaac H, Khatri Natasha, Biasini Emiliano, Massignan Tania, Huettner James E, Harris David A

Abstract excerpt

There is evidence that alterations in the normal physiological activity of PrP(C) contribute to prion-induced neurotoxicity. This mechanism has been difficult to investigate, however, because the normal function of PrP(C) has remained obscure, and there are no assays available to measure it. We recently reported that cells expressing PrP deleted for residues 105-125 exhibit spontaneous ionic currents and...

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Identifiers

PMID: 21385869
DOI: 10.1074/jbc.M110.214973
PMCID: PMC3077669

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