Article
The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.
Molecular and cellular neurosciences - 1 Jan 2005
Fioriti Luana, Quaglio Elena, Massignan Tania, Colombo Laura, Stewart Richard S, Salmona Mario, Harris David A, Forloni Gianluigi, Chiesa Roberto
Abstract excerpt
A synthetic peptide homologous to region 106-126 of the prion protein (PrP) is toxic to cells expressing PrP, but not to PrP knockout neurons, arguing for a specific role of PrP in mediating the peptide's activity. Whether this is related to a gain of toxicity or a loss of function of PrP is not clear. We explored the possibility that PrP106-126 triggered formation of PrP(Sc) or other neurotoxic PrP species. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.