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Article

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Feb 2013

Biasini Emiliano, Unterberger Ursula, Solomon Isaac H, Massignan Tania, Senatore Assunta, Bian Hejiao, Voigtlaender Till, Bowman Frederick P, Bonetto Valentina, Chiesa Roberto, Luebke Jennifer, Toselli Paul, Harris David A

Abstract excerpt

Growing evidence suggests that a physiological activity of the cellular prion protein (PrP(C)) plays a crucial role in several neurodegenerative disorders, including prion and Alzheimer's diseases. However, how the functional activity of PrP(C) is subverted to deliver neurotoxic signals remains uncertain. Transgenic (Tg) mice expressing PrP with a deletion of residues 105-125 in the central region (referred to as...

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Identifiers

PMID: 23392670
DOI: 10.1523/JNEUROSCI.3406-12.2013
PMCID: PMC3711660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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