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Article

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

The Journal of biological chemistry - 5 Mar 2010

Massignan Tania, Stewart Richard S, Biasini Emiliano, Solomon Isaac H, Bonetto Valentina, Chiesa Roberto, Harris David A

Abstract excerpt

In prion diseases, the infectious isoform of the prion protein (PrP(Sc)) may subvert a normal, physiological activity of the cellular isoform (PrP(C)). A deletion mutant of the prion protein (Delta105-125) that produces a neonatal lethal phenotype when expressed in transgenic mice provides a window into the normal function of PrP(C) and how it can be corrupted to produce neurotoxic effects. We report here the...

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Identifiers

PMID: 19940127
DOI: 10.1074/jbc.M109.064949
PMCID: PMC2844219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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