Article
A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.
Scientific reports - 15 Mar 2016
Massignan Tania, Cimini Sara, Stincardini Claudia, Cerovic Milica, Vanni Ilaria, Elezgarai Saioa R, Moreno Jorge, Stravalaci Matteo, Negro Alessandro, Sangiovanni Valeria, Restelli Elena, Riccardi Geraldina, Gobbi Marco, Castilla Joaquín, Borsello Tiziana, Nonno Romolo, Biasini Emiliano
Abstract excerpt
Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals. The structure of PrP(Sc) is poorly defined, and likely to be heterogeneous, as suggested by the existence of different prion strains. The latter represents a...
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