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Article

Channels formed with a mutant prion protein PrP(82-146) homologous to a 7-kDa fragment in diseased brain of GSS patients.

American journal of physiology. Cell physiology - 1 Oct 2003

Bahadi Randa, Farrelly Peter V, Kenna Bronwyn L, Kourie Joseph I, Tagliavini Fabrizio, Forloni Gianluigi, Salmona Mario

Abstract excerpt

A major prion protein (PrP) mutant that forms amyloid fibrils in the diseased brain of patients with Gerstmann-Sträussler-Scheinker syndrome (GSS) is a fragment of 7 kDa spanning from residues 81-82 to 144-153 of PrP. Analysis of ionic membrane currents, recorded with a lipid bilayer technique, r...

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Identifiers

PMID: 12814912
DOI: 10.1152/ajpcell.00077.2003

Genes

GSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12814912-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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