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Article

Prion peptide 106-126 as a model for prion replication and neurotoxicity.

Frontiers in bioscience : a journal and virtual library - 1 Apr 2002

Singh Neena, Gu Yaping, Bose Sharmila, Kalepu Sudheera, Mishra Ravi Shankar, Verghese Susamma

Abstract excerpt

Prion diseases or transmissible spongiform encephalopathies are neurodegenerative disorders that are genetic, sporadic, or infectious. The pathogenetic event common to all prion disorders is a change in conformation of the cellular prion protein (PrPC) to the scrapie isoform (PrPSc), which, unlike PrPC, aggregates easily and is partially resistant to protease digestion. Although PrPSc is believed to be essential...

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PMID: 11897566
DOI: 10.2741/A740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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