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Article

Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments.

The Journal of membrane biology - 1 May 2003

Kourie J I, Kenna B L, Tew D, Jobling M F, Curtain C C, Masters C L, Barnham K J, Cappai R

Abstract excerpt

We have shown previously that the protease-resistant and neurotoxic prion peptide fragment PrP[106-126] of human PrP incorporates into lipid bilayer membranes to form heterogeneous ion channels, one of which is a Cu(2+)-sensitive fast cation channel. To investigate the role of PrP[106-126]'s hydr...

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Source

Identifiers

PMID: 12879164
DOI: 10.1007/s00232-002-2005-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12879164-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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