Article

Loss of the Central Region Reshapes the Dynamic Landscape of the Cellular Prion Protein and Its Plasma Membrane Interaction

2026-05-17

Abstract excerpt

Prion diseases are fatal neurodegenerative disorders driven by the conversion of the cellular prion protein (PrP) into a misfolded, pathogenic conformer. Beyond serving as a substrate for prion propagation, PrP is also thought to mediate neurotoxic signaling. Within this framework, the central region of PrP has emerged as a critical regulatory element. Notably, deletion of residues 105–125 (ΔCR) leads to spontaneo...

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Literature Corpus work: ceed51e5-9815-5ab8-b53f-f4e99f84be94
DOI: 10.64898/2026.05.15.725371

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