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Article

The shared genetic architecture underlying the autoimmune and cardiovascular disease: a multivariate genome-wide analysis.

Cardiovascular diabetology - 11 Feb 2026

Zhang Jie, Fang Xinyu, Ye Qianling, Yin Xianyong, Ye Dongqing

Abstract excerpt

BACKGROUND: Epidemiological studies have established that autoimmune diseases (AD) increase cardiovascular disease (CVD) risk. We aimed to elucidate their shared genetic architecture and clinical implications. METHODS: We conducted a cross-trait multivariate genome-wide association study (GWAS) for three autoimmune diseases (type 1 diabetes, systemic lupus erythematosus, and rheumatoid arthritis) and four...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41673668
DOI: 10.1186/s12933-025-03041-8
PMCID: PMC12895973

Genes

IL6R
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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