Article
Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2022
Honda Suguru, Ikari Katsunori, Yano Koichiro, Terao Chikashi, Tanaka Eiichi, Harigai Masayoshi, Kochi Yuta
Abstract excerpt
OBJECTIVE: To investigate whether polygenic risk scores obtained using data from a genome-wide association study (GWAS) of rheumatoid arthritis (RA) susceptibility can be predictors of radiographic progression. METHODS: We constructed polygenic risk scores using GWAS summary data on associations of single-nucleotide polymorphisms with RA susceptibility. The polygenic risk scores were stratified into quintiles...
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