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Article

Identifying shared genetic architecture between rheumatoid arthritis and other conditions: a phenome-wide association study with genetic risk scores.

EBioMedicine - 1 Jun 2023

Zhang Harrison G, McDermott Greg, Seyok Thany, Huang Sicong, Dahal Kumar, L'Yi Sehi, Lea-Bonzel Clara, Stratton Jacklyn, Weisenfeld Dana, Monach Paul, Raychaudhuri Soumya, Yu Kun-Hsing, Cai Tianrun, Cui Jing, Hong Chuan, Cai Tianxi, Liao Katherine P

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) shares genetic variants with other autoimmune conditions, but existing studies test the association between RA variants with a pre-defined set of phenotypes. The objective of this study was to perform a large-scale, systemic screen to determine phenotypes that share genetic architecture with RA to inform our understanding of shared pathways. METHODS: In the UK Biobank (UKB),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Histocompatibility Antigens Class II

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Source

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Identifiers

PMID: 37121095
DOI: 10.1016/j.ebiom.2023.104581
PMCID: PMC10173154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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