Article
LRRK2 Pathways Leading to Neurodegeneration.
Current neurology and neuroscience reports - 1 Jul 2015
Cookson Mark R
Abstract excerpt
Mutations in LRRK2 are associated with inherited Parkinson's disease (PD) in a large number of families, and the genetic locus containing the LRRK2 gene contains a risk factor for sporadic PD. The LRRK2 protein contains several domains that suggest a role in cellular signaling, including a kinase domain. It is also clear that LRRK2 interacts, either physically or genetically, with several other important proteins...
Topics
- Animals
- Autophagy
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Neurodegenerative Diseases
- Parkinson Disease
- Protein Serine-Threonine Kinases
- Signal Transduction