A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.

doi:10.1136/annrheumdis-2011-200300

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Article

A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.

Annals of the rheumatic diseases - 1 Jun 2012

Malfait Anne-Marie, Seymour Albert B, Gao Feng, Tortorella Micky D, Le Graverand-Gastineau Marie-Pierre Hellio, Wood Linda S, Doherty Michael, Doherty Sally, Zhang Weiya, Arden Nigel K, Vaughn Frances L, Leaverton Paul E, Spector Tim D, Hart Deborah J, Maciewicz Rose A, Muir Kenneth R, Das Rosalina, Sorge Robert E, Sotocinal Susanna G, Schorscher-Petcu Ara, Valdes Ana M, Mogil Jeffrey S

Abstract excerpt

OBJECTIVES: The aim of this study was to assess if genetic variation in the PACE4 (paired amino acid converting enzyme 4) gene Pcsk6 influences the risk for symptomatic knee osteoarthritis (OA). METHODS: Ten PCSK6 single nucleotide polymorphisms were tested for association in a discovery cohort of radiographic knee OA (n=156 asymptomatic and 600 symptomatic cases). Meta-analysis of the minor allele at rs900414...

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PMID: 22440827
DOI: 10.1136/annrheumdis-2011-200300
PMCID: PMC3603144

Genes

PCSK6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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