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Article

Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.

Arthritis care & research - 1 Mar 2011

Valdes Ana M, Arden Nigel K, Vaughn Frances L, Doherty Sally A, Leaverton Paul E, Zhang Weiya, Muir Kenneth R, Rampersaud Evadnie, Dennison Elaine M, Edwards Mark H, Jameson Karen A, Javaid M Kassim, Spector Tim D, Cooper Cyrus, Maciewicz Rose A, Doherty Michael

Abstract excerpt

OBJECTIVE: To assess the genetic association of pain in patients with knee osteoarthritis (OA) and those with multiple regional pain with the R1150W variant in the α-subunit of the voltage-gated sodium channel Na(V)1.7. METHODS: Knee OA patients from 2 UK cohorts (1,411 from the Genetics of Osteo...

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PMID: 21031562
DOI: 10.1002/acr.20375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21031562-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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