Article
Single Nucleotide Polymorphism in the COL11A2 Gene Associated with Heat Pain Sensitivity in Knee Osteoarthritis.
Molecular pain - 1 Jan 2000
Ho Kwo Wei David, Wallace Margaret R, Sibille Kimberly T, Bartley Emily J, Cruz-Almeida Yenisel, Glover Toni L, King Christopher D, Goodin Burel R, Addison Adriana, Edberg Jeffrey C, Staud Roland, Bradley Laurence A, Fillingim Roger B
Abstract excerpt
Abstract: Pain is one of the most prominent symptoms of osteoarthritis. However, there is often discordance between the pain experienced by individuals with osteoarthritis and the degree of articular pathology. This suggests that individual differences, including genetic variability in the central processing of nociceptive stimuli, may impact the presentation of osteoarthritis. Here, we show that the single...
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