Article
Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene.
European journal of pain (London, England) - 1 Aug 2017
Warner S C, Walsh D A, Laslett L L, Maciewicz R A, Soni A, Hart D J, Zhang W, Muir K R, Dennison E M, Leaverton P, Rampersaud E, Cooper C, Spector T D, Cicuttini F M, Arden N K, Jones G, Doherty M, Valdes A M
Abstract excerpt
BACKGROUND: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1 ). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human studies of osteoarthritis (OA). The aim of this study was to test if genetic variation at the neurokinin 1 receptor gene (TACR1) is associated with pain in...
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