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Article

Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.

BMC genetics - 12 Dec 2017

Taipale Mari, Solovieva Svetlana, Leino-Arjas Päivi, Männikkö Minna

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is the most common degenerative joint disease afflicting people in the Western world and has a strong genetic influence. The aim of this study was to examine the association of two known functional polymorphisms in the TGF-β inhibiting genes, asporin (ASPN) and cartilage intermediate layer protein (CILP), with hand OA and potential gene-occupational hand loading interaction....

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Source

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Identifiers

PMID: 29233086
DOI: 10.1186/s12863-017-0585-4
PMCID: PMC5727665

Genes

ASPN
CILP
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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