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Article

Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene.

European journal of human genetics : EJHG - 1 Apr 2017

Warner Sophie C, van Meurs Joyce Bj, Schiphof Dieuwke, Bierma-Zeinstra Sita M, Hofman Albert, Uitterlinden Andre G, Richardson Helen, Jenkins Wendy, Doherty Michael, Valdes Ana M

Abstract excerpt

Neuropathic pain-like joint symptoms (NP) are seen in a proportion of individuals diagnosed with osteoarthritis (OA) and post total joint replacement (TJR). In this study, we performed a genome-wide association study (GWAS) using NP as defined by the painDETECT questionnaire (score >12 indicating possible NP) in 613 post-TJR participants recruited from Nottinghamshire (UK). The prevalence of possible NP was...

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Identifiers

PMID: 28051079
DOI: 10.1038/ejhg.2016.196
PMCID: PMC5386416

Genes

PRKCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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