Article
The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.
Annals of the rheumatic diseases - 1 Sept 2011
Valdes Ana M, De Wilde Gert, Doherty Sally A, Lories Rik J, Vaughn Frances L, Laslett Laura L, Maciewicz Rose A, Soni Anushka, Hart Deborah J, Zhang Weiya, Muir Kenneth R, Dennison Elaine M, Wheeler Margaret, Leaverton Paul, Cooper Cyrus, Spector Tim D, Cicuttini Flavia M, Chapman Victoria, Jones Graeme, Arden Nigel K, Doherty Michael
Abstract excerpt
OBJECTIVE: To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA). METHODS: The Ile585Val TRPV1 variant encoded by rs8065080 was genotyped in 3270 cases of symptomatic knee OA, 1098 cases of asymptomatic knee OA and 3852 controls from seven cohorts from the UK, the USA and...
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